METHOD FOR SIMULTANEOUSLY EXTRACTING THE INPUT FUNCTION AND PHARMACOKINETIC PARAMETERS OF AN ACTIVE INGREDIENT

摘要

This extraction method in a structure of a living organism from a measurement image of the kinetics of the active ingredient comprising a plurality of regions of interest inside each of which the kinetics of the active ingredient are measured, comprises the following steps: determining (30) a plurality of sets of kinetics, the determined sets of kinetics being different from each other and each determined set of kinetics including several measured kinetics; defining (32) at least one kinetic model, parameters of the defined kinetics model being formed by the parameters of the input function and the pharmacokinetic parameters; estimating (34) the input function and the pharmacokinetic parameters by resolving the kinetic model defined from the determined set of kinetics; and deducing (36) the final input function and the final pharmacokinetic parameters.