发明名称 |
HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS |
摘要 |
Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin-dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.
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申请公布号 |
US2011224227(A1) |
申请公布日期 |
2011.09.15 |
申请号 |
US200913122061 |
申请日期 |
2009.10.01 |
申请人 |
SHARPLESS NORMAN E;STRUM JAY C;BISI JOHN E;ROBERTS PATRICK J;RAMSEY MATTHEW R |
发明人 |
SHARPLESS NORMAN E.;STRUM JAY C.;BISI JOHN E.;ROBERTS PATRICK J.;RAMSEY MATTHEW R. |
分类号 |
A61K31/497;A61K31/4709;A61K31/505;A61K31/519;A61P39/00;G01N33/53 |
主分类号 |
A61K31/497 |
代理机构 |
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地址 |
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