| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a spiroheterocyclic compound of formula (I): ^ , ^ where: p equals 1-4; j and k are each independently equal to 0, 1, 2 or 3; Q denotes -O-, denotes a condensed 5-member heteroaryl ring with one S atom or a 6-member heteroaryl ring with one N atom; R1 denotes C1-8alkyl; each R2 independently denotes H, C1-8alkyl; each R3a, R3b R3c and R3d independently denotes H, C1-8alkyl, or R3a and R3b, or R3b and R3c, or R3c and R3d, together with carbocycle atoms to which they are directly bonded, can form a condensed dioxolyl ring, and the remaining group R3a, R3b R3c or R3d is as described above; or a pharmaceutically acceptable salt thereof. ^ EFFECT: compounds can be used to treat sodium channel-mediated diseases or conditions such as pain. ^ 13 cl, 4 dwg, 2 tbl, 9 ex |
