发明名称 |
COMPOUNDS THAT SUPPRESS CANCER CELLS AND EXHIBIT ANTITUMOR ACTIVITY |
摘要 |
The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitro and antitumor response in vivo. |
申请公布号 |
WO2010117438(A3) |
申请公布日期 |
2011.09.09 |
申请号 |
WO2010US01021 |
申请日期 |
2010.04.05 |
申请人 |
UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.;UNIVERSITY OF TORONTO MISSISSAUGA;TURKSON, JAMES;GUNNING, PATRICK |
发明人 |
TURKSON, JAMES;GUNNING, PATRICK |
分类号 |
A61K31/63;A61K31/025;A61K31/13 |
主分类号 |
A61K31/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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