A TRANSGENIC PORCINE CLONAL SOMATIC CELL LINE EXPRESSING HUMAN FASL PROTEIN TO INHIBIT CELLULAR IMMUNITY AND TRANSGENIC CLONE PIG USING THE SAME
摘要
PURPOSE: A transgenic porcine clonal somatic cell line which expresses human FasL gene in a tissue and cells is provided to reduce cytotoxicity and to minimize immune rejection. CONSTITUTION: A transgenic porcine clonal cell line contains human FasL gene expression vector and is deposited in the number KCLRF-BP-00194. A method for preparing the somatic cell line comprises: a step of isolating somatic cells from porcine fetus; a step of preparing hFasL gene expression vector and introducing to the somatic cells; and a step of selecting expression vector-introduced somatic cells and culturing.
申请公布号
KR20110093132(A)
申请公布日期
2011.08.18
申请号
KR20100012983
申请日期
2010.02.11
申请人
MGEN INC.;HEO, JAE YOUNG
发明人
HEO, JAE YOUNG;CHOI, KI MYUNG;SEOL, JAE GOO;HONG, SEUNG PYO;PARK, KWANG WOOK;YOO, JI YEON;KIM, SOO HYUN;PARK, YOUNG CHOL;YUN, YUN JIN