PROBES COMPRISING FLUORESCENT ARTIFICIAL NUCLEOBASES AND USE THEREOF FOR DETECTION OF SINGLE BASE ALTERATION
摘要
The present invention relates to forced intercalation probes (FIT-probes) comprising at least one nucleoside analogue which comprises at least a fluorescent artificial nucleobase directly bound to a carbon of a modified sugar moiety wherein said modified sugar moiety is a carba-sugar or an amino acid nucleic acid (AANA). Thereby the nucleoside analogue is incorporated into DNA or RNA in the place of a single native base.
申请公布号
WO2011029835(A3)
申请公布日期
2011.08.18
申请号
WO2010EP63156
申请日期
2010.09.08
申请人
HUMBOLDT-UNIVERSITAET ZU BERLIN;SEITZ, OLIVER;BETHGE, LUCAS;HAINKE, SVEN