| 发明名称 |
GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES |
| 摘要 |
Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. |
| 申请公布号 |
EP2352369(A1) |
申请公布日期 |
2011.08.10 |
| 申请号 |
EP20090830727 |
申请日期 |
2009.12.03 |
| 申请人 |
SANGAMO BIOSCIENCES, INC.;SIGMA ALDRICH COMPANY |
发明人 |
CUI, Xiaoxia;GEURTS, Aron M.;URNOV, Fyodor |
| 分类号 |
A01K67/027;C12N9/22;C12N15/11;C12N15/85 |
主分类号 |
A01K67/027 |
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