发明名称 |
Functionalized diarylisoxazoles inhibitors of ciclooxygenase |
摘要 |
Isoxazole derivatives, in particular diarylisoxazole derivatives inhibitors of cyclooxygenase (COX), in particular cyclooxygenase-1 (COX-1), their pharmaceutical compositions, the process for their preparation and their use for the chemoprevention and treatment of inflammatory syndromes and in the prevention and treatment of carcinomas, in particular intestinal, ovarian and cutaneous carcinomas, in the treatment of pain syndromes, in particular after surgery, and in the cardiovascular field as antithrombotics/vasoprotectives/cardioprotectives.
|
申请公布号 |
US7989450(B2) |
申请公布日期 |
2011.08.02 |
申请号 |
US20080007571 |
申请日期 |
2008.01.11 |
申请人 |
UNIVERSITA' DEGLI STUDI DI BARI;UNIVERSITA' DEGLI STUDI &LDQUO,G.D.'ANNUNZIO&RDQUO,&MDASH,CHIETI |
发明人 |
SCILIMATI ANTONIO;VITALE PAOLA;DI NUNNO LEONARDO;PATRIGNANI PAOLA;TACCONELLI STEFANIA;CAPONE MARTA LUCIANA |
分类号 |
A61K31/42;A61K31/5355;C07D261/08;C07D413/06 |
主分类号 |
A61K31/42 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|