发明名称 |
MODIFIED SOLUBLE FGF RECEPTOR FC FUSIONS WITH IMPROVED BIOLOGICAL ACTIVITY |
摘要 |
The invention relates to modified soluble FGF receptor Fc fusions comprising a fusion of a soluble fragment or domain of the FGF receptor part (targeting or binding moiety) with an Fc region of an immunoglobulin part (effector function moiety), having improved biological activity including ADCC/CDC activities, compositions containing them, and method of producing such modified soluble FGF receptor Fc fusion molecules. |
申请公布号 |
PT2092069(E) |
申请公布日期 |
2011.07.29 |
申请号 |
PT20070866627T |
申请日期 |
2007.11.28 |
申请人 |
AVENTIS PHARMA S.A. |
发明人 |
MARK NESBIT;BEATRICE CAMERON;FRANCIS BLANCHE;SYLVIE SORDELLO;CELINE NICOLAZZI;MARC TROMBE |
分类号 |
C12N15/62;A61K38/17;A61K47/48;C07K14/47;C07K14/71 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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