| 摘要 |
<p>The present invention relates to a coccidiosis vaccine to protect poultry against Eimeria infection, comprising a recombinant avian adenovirus vector comprising in frame a (heterologous) promoter linked to a hydrophobic signal sequence for membrane anchoring, or linked to an hydrophobic secretion signal and a cleavage site to allow secretion; a multiple cloning site for in frame insertion of an <i>Eimeria</i> antigen ORF such as derived from the r56, 82 kDa, and/or TFP250 antigens; a polyadenylation signal; and an avian adenovirus genome.</p> |
