发明名称 |
PAPILLOMAVIRUS-LIKE PARTICLES (VLP) AS BROAD SPECTRUM HUMAN PAPILLOMAVIRUS (HPV) VACCINES |
摘要 |
This invention relates, e.g., to a virus-like particle (VLP) composition assembled from a chimeric polypeptide comprising a papilloma virus (e.g., human papillomavirus, or HPV) L1 major capsid protein, into which is inserted a surface-displayed peptide comprising a neutralizing epitope of a papillomavirus L2 protein. Vaccine compositions comprising the VLP are described, as well as methods for inducing an immune response (e.g., vaccinating) a subject against papilloma virus, using the VLP, and kits comprising the VLP, for carrying out a method of the invention. |
申请公布号 |
WO2010118424(A3) |
申请公布日期 |
2011.05.26 |
申请号 |
WO2010US30757 |
申请日期 |
2010.04.12 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;RODEN, RICHARD, B.S.;KIRNBAUER, REINHARD;SCHELLENBACHER, CHRISTINA |
发明人 |
RODEN, RICHARD, B.S.;KIRNBAUER, REINHARD;SCHELLENBACHER, CHRISTINA |
分类号 |
A61K38/16;A61K39/12;A61P31/12 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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