发明名称 8-AZABICYCLO[3.2.1]OCTYL-2-HYDROXYBENZAMIDE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
摘要 The invention provides 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds of formula (I): wherein R2, R7, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
申请公布号 US2011118306(A1) 申请公布日期 2011.05.19
申请号 US201113014012 申请日期 2011.01.26
申请人 THERAVANCE, INC. 发明人 SAITO DAISUKE ROLAND;LONG DANIEL D.;VAN DYKE PRISCILLA;CHURCH TIMOTHY J.;JIANG LAN;FRIEMAN BRYAN
分类号 A61K31/46;A61P1/00 主分类号 A61K31/46
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