AN ORAL VACCINE TO PROTECT ANIMALS AGAINST PLAGUE

摘要

A vaccine against plague for animals is disclosed comprising a recombinant raccoon poxvirus having at least one heterologous nucleic acid sequence translating for a protein antigenic for Y. pestis. The heterologous nucleic acid sequence of the vaccine comprises a novel truncated form of the V gene of Y. pestis, or some combination the novel sequence and the sequence translating for the F1-antigen of Y. pestis. We further disclose an oral vaccine compromising a recombinant raccoon poxvirus suitable for administration as bait or feed to animals in the wild.