摘要 |
<P>PROBLEM TO BE SOLVED: To provide a prophylactic or therapeutic agent for diabetes, diabetic complications, diabetic microangiopathy complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, heart failure, cardiomyopathy, myocardial ischemia, cerebral ischemia, stroke, pulmonary hypertension, hyperlactatemia, mitochondrial disorders, mitochondrial encephalomyopathy or cancer, i.e., a PDHK inhibitor or the like. <P>SOLUTION: There is specifically disclosed a compound represented by general formula [I], a pharmaceutically acceptable salt of the compound, or a solvate of the compound or the pharmaceutically acceptable salt. In the formula, R<SP>a</SP>is (1) a hydrogen atom, or (2) a halogen atom; R<SP>b</SP>is (1) a hydrogen atom, (2) a halogen atom, (3) a 1-6C alkyl group, (4) a 2-6C alkenyl group or the like; R<SP>c</SP>is (1) a hydrogen atom, (2) a halogen atom, (3) a 1-6C alkyl group, (4)-C(=O)-OR<SP>c1</SP>(in the formula, R<SP>c1</SP>shows a hydrogen atom or a 1-6C alkyl group) or the like; X<SP>d</SP>is (1) a nitrogen atom or (2) C-R<SP>d</SP>[in the formula, R<SP>d</SP>is (i) a hydrogen atom, (ii) a halogen atom, (iii) a 1-6C alkyl group, (iv) a 2-6C alkenyl group] or the like; R<SP>e</SP>is the same or different, (1) a halogen atom or (2) a 1-6C alkyl group; and n is 0 or an integer of 1-3. <P>COPYRIGHT: (C)2011,JPO&INPIT |