<p>Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.</p>
申请公布号
WO2011031330(A1)
申请公布日期
2011.03.17
申请号
WO2010US02494
申请日期
2010.09.14
申请人
ENZO LIFE SCIENCES, INC.;PATTON, WAYNE, FORREST;COLEMAN, JACK;XIANG, YUEJUN;PANDE, PRAVEEN;LI, ZAIGUO;SHEN, DEE
发明人
PATTON, WAYNE, FORREST;COLEMAN, JACK;XIANG, YUEJUN;PANDE, PRAVEEN;LI, ZAIGUO;SHEN, DEE