IBD-ASSOCIATED MICROBIAL ANTIGEN AND METHOD OF USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide nucleic acid sequence and amino acid sequence of the novel I-1 and I-2 polypeptides, which are associated with human inflammatory bowel disease (IBD).

SOLUTION: There are provided: an isolated inflammatory bowel disease-associated I-2 polypeptide having substantially the same amino acid sequence as a specific amino acid sequence; substantially purified antibody material that selectively binds an I-2 polypeptide having a specific amino acid sequence; and methods of diagnosing and treating inflammatory bowel disease using the IBD-associated I-1 and I-2 antigens.

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