PREPARATION METHOD OF 2-(2-PHTHLIMIDOETHOXY) ACETIC ACID

摘要

PURPOSE: A method for preparing 2-(2-phthalimidoethoxy)acetic acid is provided to cheaply obtain 2-(2-phthalimidoethoxy)acetic acid of high purity. CONSTITUTION: A 2-(2-phthalimidoethoxy)acetic acid is prepared by dropping sodium chloride(NaClO_2) solution and sodium hyperchloride(NaOCl) solution to 2-(2-phthalimidoethoxy)ethanol of chemical formula 3 under the presence of 2,2,6,6-tetramethylpiperidine 1-oxyl(TEMPO) catalyst and oxidizing 2-(2-phthalimidoethoxy)ethanol. The 2-(2-phthalimidoethoxy)ethanol is used in an organic solvent of nitrile, ketone, haloalkan, or ester or water and buffer solution. The organic solvent is aceto nitrile, acetone, methyl ethyl ketone, dichlomethane, dichloroethan, or ethyl acetate.