发明名称 |
Methods for Improving Protein Performance |
摘要 |
The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for altering the net surface charge and/or surface charge distribution of enzymes {e.g., metalloproteases or serine proteases) to obtain enzyme variants that demonstrate improved performance in detergent formulations as compared to the starting or parent enzyme.
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申请公布号 |
US2010297727(A1) |
申请公布日期 |
2010.11.25 |
申请号 |
US20080602985 |
申请日期 |
2008.06.06 |
申请人 |
AEHLE WOLFGANG;CASCAO-PEREIRA LUIS GUSTAVO;KELLIS JR JAMES T;SHAW ANDREW |
发明人 |
AEHLE WOLFGANG;CASCAO-PEREIRA LUIS GUSTAVO;KELLIS, JR. JAMES T.;SHAW ANDREW |
分类号 |
C12N9/08;C12N9/02;C12N9/10;C12N9/16;C12N9/18;C12N9/26;C12N9/42;C12N9/48 |
主分类号 |
C12N9/08 |
代理机构 |
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地址 |
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