METHODS FOR MODULATING ADIPOCYTE EXPRESSION USING MICRORNA COMPOSITIONS

摘要

Disclosed are compositions and methods useful for modulating adipocyte differentiation and/or development. Also disclosed are compounds, compositions, and methods useful for altering the expression and/or activity of one or more genes involved in pathways relating to adipogenesis and/or adipocyte activity both in vitro and in vivo. In particular, the present invention provides small interfering nucleic acid molecules, and in particular, micro- RNA and miR-155-derived molecules, and methods for their use in altering the expression, regulation, or accumulation of one or more adipogenic or anti-adipogenic genes or a gene products in a mammal,