发明名称 |
SOLUBLE AND MEMBRANE ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS |
摘要 |
The invention discloses compositions comprising soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins. This invention further relates to diagnostic and preventative methods using these compositions. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules) that inhibit LASV infectivity. Further, the invention relates to diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses.
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申请公布号 |
US2010261640(A1) |
申请公布日期 |
2010.10.14 |
申请号 |
US20080450756 |
申请日期 |
2008.04.10 |
申请人 |
BRANCO LUIS M;MATSCHINER ALEXANDER;ILLICK MEGAN M;SAMPEY DARRYL B;GARRY ROBERT F;BAUSCH DANIEL G;FAIR JOSEPH N;GUTTIERI MARY C;CASHMAN KATHLEEN A;WILSON RUSSELL B;KULAKOSKY PETER C;GESKE F JON |
发明人 |
BRANCO LUIS M.;MATSCHINER ALEXANDER;ILLICK MEGAN M.;SAMPEY DARRYL B.;GARRY ROBERT F.;BAUSCH DANIEL G.;FAIR JOSEPH N.;GUTTIERI MARY C.;CASHMAN KATHLEEN A.;WILSON RUSSELL B.;KULAKOSKY PETER C.;GESKE F. JON |
分类号 |
A61K38/16;A61P31/14;C07H21/04;C07K14/08;C07K16/10;C12N15/63;C12P21/02;C12Q1/70 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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