Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses

摘要

Disclosed is a compound of formula (I), or a salt, hydrate, solvate, or N-oxide thereof, that is enriched in the diastereoisomers of formula (Ia), where the substituents in each formula are as defined in the specification. Also disclosed is the use of the compound for inhibiting proliferation in a cell, such as a tumor cell, and for inhibiting an Aurora kinase mediated process