THERAPEUTIC AGENT FOR CANCER HAVING REDUCED SENSITIVITY TO MOLECULAR TARGETED DRUG AND PHARMACEUTICAL COMPOSITION FOR ENHANCING SENSITIVITY TO MOLECULAR TARGETED DRUG

摘要

Disclosed is a pharmaceutical composition which can enhance the sensitivity of cancer having tolerance to a molecular targeted drug such as gefitinib and erlotinib to the molecular targeted drug.  Also disclosed is a cancer therapeutic agent which is effective on cancer having tolerance to a molecular targeted drug such as gefitinib and erlotinib.  The pharmaceutical composition comprises an HGF-MET receptor system inhibitor, and can enhance the sensitivity of cancer having tolerance to a molecular targeted drug to the molecular targeted drug.  The cancer therapeutic gent comprises a combination of a molecular targeted drug and an HGF-MET receptor system inhibitor, and is effective on cancer having tolerance to a molecular targeted drug.