发明名称 |
CARDIOMYOCYTES-CONTAINING DEVICE AND METHOD FOR MANUFACTURING AND USING THE SAME |
摘要 |
<p>Disclosed is a device for determining the cardiotoxicity of a chemical compound, comprising a substrate (10) carrying a deformable stack (34), said stack being partially detached from the substrate by a cavity (32) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer (16), a second deformable layer (20) and a multi-electrode structure (18) sandwiched between the first and second deformable layers, the second deformable layer carrying a pattern of cardiomyocytes (28) adhered thereto; and a liquid container (26) mounted on the substrate for exposing the cardiomyocytes to the chemical compound. A method of manufacturing such a device is also disclosed. The present invention further relates to the use of the device for drug target discovery and/or drug development and a method for developing a disease model for a disease that is caused by or modified by stretching of cells, in particular a cardiac disease model.</p> |
申请公布号 |
WO2010089718(A1) |
申请公布日期 |
2010.08.12 |
申请号 |
WO2010IB50537 |
申请日期 |
2010.02.05 |
申请人 |
KONINKLIJKE PHILIPS ELECTRONICS N.V.;DEKKER, RONALD;VAN DE STOLPE, ANJA |
发明人 |
DEKKER, RONALD;VAN DE STOLPE, ANJA |
分类号 |
C12M3/04;C12N5/00 |
主分类号 |
C12M3/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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