PROCESS FOR THE PREPARATION OF 3, 4-DIHYDRO-2H-THIEN [3, 2-E] -1, 2-THIAZIN-4-OL 1, 1 -DIOXIDE DERIVATIVES AND INTERMEDIATES

摘要

The present invention relates to a process for the preparation of Brinzolamide, or 2H-thieno [3, 2-e]-1, 2- thiazin-6-sulfonamide, 4-(ethyl amino)-3, 4-dihydro-2-(3- methoxypropyl)-, 1,1-dioxide,(4R)- via intermediates 2, 3-dihydro-4H-thieno [3,2-e]-1, 2-thiazin-4-ones, 1,1- dioxide. Further objects of the present invention are the intermediates mentioned above and other intermediates of the synthesis.