| 摘要 |
In one aspect, the present invention provides for a compound of Formula I; in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.
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| 申请人 |
ABBOTT LABORATORIES;GENENTECH, INC.;THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH |
发明人 |
BAELL, JONATHON BAYLDON;BUI, CHINH THIEN;COLMAN, PETER;CZABOTAR, PETER;DUDLEY, DANETTE A.;FAIRBROTHER, WAYNE J.;FLYGARE, JOHN A.;LASSENE, GUILLAUME LAURENT;NDUBAKU, CHUDI;NIKOLAKOPOULOS, GEORGE;SLEEBS, BRAD EDMUND;SMITH, BRIAN JOHN;WATSON, KEITH GEOFFREY;ELMORE, STEVEN W.;HASVOLD, LISA A.;PETROS, ANDREW M.;SOUERS, ANDREW J.;TAO, ZHI-FU;WANG, LE;WANG, XILU;DESHAYES, KURT |
