The use of a selected aminoalkyl glusoaminide 4-phosphate (AGP) CRX-547 to induce a TRIF biased response in a human system, which results in reduced levels of MyD88-dependent cytokines relative to the MyD88-dependent cytokines induced by its diastereomer AGP CRX-527.
申请公布号
CA2748038(A1)
申请公布日期
2010.07.01
申请号
CA20092748038
申请日期
2009.12.23
申请人
GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人
JOHNSON, DAVID A.;EVANS, JAY T.;HUTTON, MELINDA M.;BOWEN, WILLIAM S.;MINNS, LAURIE A.
