发明名称 |
Method for Preparing a Covalently Cross Linked Oligomer of Amyloid Beta Peptides |
摘要 |
The invention relates to a method for the preparation of a stabilized cross-linked oligomer of amyloid beta using a near-zero length bifunctional cross-linking agent for use as an immunogen for the generation of antibodies for the treatment of Alzheimer's Disease and other conditions related to abnormal amyloid beta aggregation. A preferred bifunctional cross-linking agent is 1,5-difluoro-2,4-dinitrobenzene (DFDNB).
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申请公布号 |
US2010143396(A1) |
申请公布日期 |
2010.06.10 |
申请号 |
US20060922552 |
申请日期 |
2006.06.26 |
申请人 |
GRIMM KAREN M;JOYCE JOSEPH G;LIANG XIAOPING;NAWROCKI DENISE |
发明人 |
GRIMM KAREN M.;JOYCE JOSEPH G.;LIANG XIAOPING;NAWROCKI DENISE |
分类号 |
A61K39/385;A61P25/28;C07K1/00;C07K1/16 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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