发明名称 |
FUSION POLYPEPTIDE SUITABLE AS A CYTOTOXIN |
摘要 |
The present invention relates to fusion polypeptides including (a) a binding site for a cytoskeleton component and (b1) an effector protein or the catalytic domain thereof or (b2) a binding site for the effector protein, and nucleic acid sequences encoding the fusion polypeptides. Moreover, various therapeutic uses of the fusion polypeptides are described, e.g., the treatment of diseases associated with the presence of an aberrant cell population, preferably cancer or AIDS. |
申请公布号 |
US2010144847(A1) |
申请公布日期 |
2010.06.10 |
申请号 |
US20090496179 |
申请日期 |
2009.07.01 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS |
发明人 |
NUESCH JURG;ROMMELAERE JEAN |
分类号 |
A61K31/7088;A01K67/00;A61P31/12;A61P35/04;C07H21/04;C07K14/015;C07K16/08;C12N1/15;C12N1/21;C12N5/10;C12N9/12;C12N9/96;C12N15/63 |
主分类号 |
A61K31/7088 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|