发明名称 THIENOTRIAZOLODIAZEPINE DERIVATIVES ACTIVE ON APO A
摘要 The invention relates to new thienotriazolodiazepine derivatives of the formula (1) wherein R1 is CH3, R2 is CH3 or -(CH2)n-R4 or -(CH2)n-O-R4 or -(CH2)n-S-R4 wherein n is 1, 2, 3 or 4 and R4 is CH3, CH2CH3 or CH2CH2OCH3, and R3 is hydrogen or -OCH2O- or -OCH2CH2O- connected to the ortho/meta position or meta/para position of the phenyl ring; or wherein R1 and R2 are hydrogen and R3 is -OCH2O- Or -OCH2CH2O- connected to the ortho/meta position or meta/para position of the phenyl ring; and pharmaceutically acceptable acid addition salts thereof. These compounds and pharmaceutical compositions containing them are useful in the treatment and prevention of atherosclerotic artery diseases, such as myocardial infarction and stroke, and of Alzheimer's disease.
申请公布号 CA2741934(A1) 申请公布日期 2010.05.06
申请号 CA20092741934 申请日期 2009.10.29
申请人 CIRCOMED LLC 发明人 KEMPEN, HERMAN;BELLUS, DANIEL;STAEHELIN, BARBARA
分类号 C07D495/14;A61K31/551;A61P9/00 主分类号 C07D495/14
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