发明名称 |
Protein D—an IGD binding protein of Haemophilus influenzae |
摘要 |
A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid sequence.
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申请公布号 |
USRE41277(E1) |
申请公布日期 |
2010.04.27 |
申请号 |
US20080285368 |
申请日期 |
2008.10.02 |
申请人 |
FORSGREN ARNE |
发明人 |
FORSGREN ARNE |
分类号 |
A61K39/00;A61K39/102;A61K38/00;A61P31/04;C07K14/005;C07K14/195;C07K14/285;C07K14/41;C07K14/705;C07K16/00;C07K16/12;C07K19/00;C12N1/21;C12N5/10;C12N15/02;C12N15/09;C12N15/31;C12P21/00;C12P21/08;C12R1/19;C12R1/21;C12R1/91;G01N33/53;G01N33/569;G01N33/577 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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