| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to pharmacology, namely to creation of a new inter- and intra- multilayer vesicular composition containing a drug dithranol used for psoriasis treatment. A controlled release vesicular composition used for drug delivery containing a set of dispersed concentric two-layer vesicles with an external layer enclosing an aqueous hydrocolloid gelling agent, and an internal layer being a lipid phase. Both layers have a drug dispersed in the concentration 70-80% in the internal layer and 20-30% in the external layer. Particularly, the composition contains as follows, %: dithranol 0.25-1.0; phospholipid 8-12; cholesterol 3-7; butylated hydroxytoluol 0.1-0.5; hydrocolloid gelling agent 0.5-3.0; a phosphate salt buffer - the rest. The average vesicle size in the composition varies in the range 1-10 micron. The hydrocolloid gelling agent possesses thixotropic rheological characteristic and particularly represents methyl cellulose. Besides the invention concerns application of said composition for drug delivery for treatment of dermal problems, particularly psoriasis. The invention improves efficiency of molecules of the drug in a reduced dose, makes the composition more acceptable with relation to rheology, and stable, provides the absence of irritation and stains formation, is easily applied (remains on an injured area). The declared composition can contain the increased amount of the drug without irritation and stains formation when severity of disease requires increased doses. ^ EFFECT: product is characterised by improved therapeutic properties of dithranol combined with some other favourable properties. ^ 6 cl, 1 ex |
