发明名称 |
Modulating cancer cell characteristics |
摘要 |
The hedgehog pathway in cerebellar cancer cells was modulated with siRNA specifically targeted to the shh and gli-I genes. Silencing of the two genes in a medullablastoma cell line transfected with the siRNAs caused significant reduction of mRNA specific for the targeted shh and gli-I genes and a loss of protein expression. The disclosed methods and compositions may be useful for treatment of a range of primitive neuroectodermal tumors (PNET) by shutting down or modulating the expression of gene products associated with the hedgehog pathway.
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申请公布号 |
US7666676(B2) |
申请公布日期 |
2010.02.23 |
申请号 |
US20060436962 |
申请日期 |
2006.05.16 |
申请人 |
ST. JOSEPH'S CHILDREN'S HOSPITAL |
发明人 |
LAWMAN MICHAEL J. P.;BRACCILI SELENA |
分类号 |
C12N15/00;C07H21/04;C12N5/00 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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