METHOD FOR PREPARATION OF MICELLAR HYBRID NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS AND COMPOSITIONS THEREOF

摘要

The disclosure provides a long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single polyethylene glycol (PEG) -phospholipid micelle and provide the first examples of simultaneous targeted drug delivery and dual-mode NIR- fluorescent and MR imaging of diseased tissue in vitro and in vivo.