Pyrrolo-triazine aniline compounds useful as kinase inhibitors for treating inflammatory disorders

摘要

Pyrrolo-triazine aniline compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, that are useful as kinase inhibitors are disclosed, wherein R1, R2, R3, R4, R5, R6, m, X and Z are as described in the specification. These compounds are suitable for an treating inflammatory disorder selected from asthma, adult respiratory distress syndrome, chronic obstructive pulmonary disease, chronic pulmonary inflammatory disease, diabetes, inflammatory bowel disease, osteoporosis, psoriasis, graft vs. host rejection, atherosclerosis, and arthritis including rhematoid arthritis, psoriatic arthritis, traumatic arthritis, rubella arthritis, gouty arthritis and osteoarthritis.