METHYLENE-4-AZASTEROIDS, THEIR USE AS 5 - ALPHA REDUCTASE INHIBITOR, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND METHOD FOR THEIR PRODUCTION

摘要

17-methylene-4-azasteroid compounds of formula I: wherein R²⁰ denotes fluoro, chloro or bromo R^20a denotes hydrogen, R¹⁰ and R⁴ each denote a hydrogen atom or a methyl group, and R¹ and R² each denote a hydrogen atom or together denote an additional bond, are useful for treating diseases or conditions caused by excessive androgen levels, such as acne, prostate diseases, alopecia and hirsutism, as well as gynecological conditions. Methods of synthesizing the new 17-methylene-4-azasteroid compounds are described.