SOLUBLE INFLUENZA VACCINE

摘要

The invention provides fusion proteins comprising: (i) a first portion comprising an influenza A M2e polypeptide, and (ii) a second portion comprising a rotaviral NSP4 polypeptide. The fusion proteins mimics the native tetrameric structure of native M2 protein. Additionally it is highly soluble and as disclosed herein can be produced and isolated in large quantities extremely quickly and efficiently. Also provided are related materials and methods, including use of the fusion proteins as vaccines.