发明名称 |
METHOD FOR IDENTIFYING CELLS SUITABLE FOR LARGE-SCALE PRODUCTION OF RECOMBINANT PROTEINS |
摘要 |
The present invention provides methods of identifying a clonal population of cells suitable for large-scale production of a protein of interest. The invention further provides methods for high-throughput screening for genetic rearrangements in the gene encoding the protein of interest, whereby the absence of a deletion in the gene encoding the protein of interest indicates that the cell is suitable for large-scale production of the protein of interest.
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申请公布号 |
CA2716801(A1) |
申请公布日期 |
2009.09.17 |
申请号 |
CA20092716801 |
申请日期 |
2009.03.12 |
申请人 |
WYETH LLC |
发明人 |
MCCARTHY, KEVIN;HONE, MEGAN;HELLER-HARRISON, ROBIN;LEONARD, MARK |
分类号 |
C12P21/00;C12N15/10;C12N15/85;C12N15/90 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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