发明名称 |
Modified Insulin and conjugates thereof |
摘要 |
A method for protecting a peptide from peptidase activity in vivo , the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a reactive group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity. |
申请公布号 |
EP2100901(A1) |
申请公布日期 |
2009.09.16 |
申请号 |
EP20080158878 |
申请日期 |
2000.05.17 |
申请人 |
CONJUCHEM BIOTECHNOLOGIES INC. |
发明人 |
BRIDON, DOMINIQUE P.;EZRIN, ALAN M.;HOLMES, DARREN L.;THIBAUDEAU, KAREN;MILNER, PETER G. |
分类号 |
A61K47/42;C07K14/575;A61K38/00;A61K38/02;A61K47/48;A61P1/18;A61P5/00;A61P5/48;A61P25/00;A61P25/28;A61P43/00;C07K1/107;C07K1/113;C07K1/14;C07K2/00;C07K7/00;C07K14/00;C07K14/16;C07K14/465;C07K14/605;C07K14/62;C07K14/645;C07K14/76 |
主分类号 |
A61K47/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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