发明名称 |
ANTIOXIDANT AND PARAMAGNETIC HEPARIN-NITROXIDE DERIVATIVES |
摘要 |
The present invention relates to novel heparin-nitroxide derivatives comprising heparin and at least two and more nitroxides/polynitroxide radicals that are covalently coupled to heparin by derivatisation of glycosaminoglycan carboxyl or amino groups. The heparin-nitroxide derivatives are useful as therapeutic or diagnostic agents. This invention further concerns novel methods for the production of the heparin-nitroxide agents, and methods of their uses for specifically targeting and labelling of biological vessels. The inventions also suggest the uses of the heparin-nitroxide derivatives for treatment of oxidative stress-mediated diseases. Furthermore, the heparin-nitroxide derivatives according to the present invention are in particular useful for electron paramagnetic resonance imaging (EPRI), for magnetic resonance imaging (MRI), and for preservation of biological transplants. |
申请公布号 |
WO2009027056(A3) |
申请公布日期 |
2009.08.13 |
申请号 |
WO2008EP06901 |
申请日期 |
2008.08.22 |
申请人 |
JOHANNES GUTENBERG-UNIVERSITAET MAINZ VERTRETEN DURCH DEN PRAESIDENTEN;KLESCHYOV, ANDREY;MUENZEL, THOMAS;GOLUBEV, VALERY;SEN, VASILY |
发明人 |
KLESCHYOV, ANDREY;MUENZEL, THOMAS;GOLUBEV, VALERY;SEN, VASILY |
分类号 |
A61K31/727;A61K31/445;A61K45/06;A61P7/00;A61P39/06 |
主分类号 |
A61K31/727 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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