RESISTANCE CIRCUIT STABILIZATION AND PULSE DURATION CONTROL SYSTEMS FOR ELECTROPORATION INSTRUMENTS

摘要

Systems, methods and apparatus for stabilizing resistance measurements in electroporation systems so as to achieve high-accuracy measurements, and for controlling the pulse duration, or time constant, of electroporation pulses. Circuitry is provided to accurately determine the resistance Rs of a sample 25 in the electroporation system, for example a sample 25 provided in an electroporation cuvette. Additionally, a resistance control system is provid ed to automatically measure the resistance of a sample 25, determine a capacitance and determine a parallel add-on resistance R2 that substantially provides a desired pulse duration (time constant) for an electroporation pul se.