发明名称 MALEATE SALTS OF (E)-N--4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF
摘要 The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
申请公布号 US2009176827(A1) 申请公布日期 2009.07.09
申请号 US20080251924 申请日期 2008.10.15
申请人 WYETH 发明人 LU QINGHONG;KU MANNCHING SHERRY;CHEW WARREN;CHEAL GLORIA;HADFIELD ANTHONY F.;MIRMEHRABI MAHMOUD
分类号 A61K31/4709;C07D401/12;C07D401/14 主分类号 A61K31/4709
代理机构 代理人
主权项
地址