发明名称 |
METHOD FOR NONINVASNELY AND QUANTITATIVELY MONITORING THERAPEUTIC AND DIAGNOSTIC TRANSGENE EXPRESSION INDUCED BY EX VNO AND IN VNO GENE TARGETING IN ORGANS, TISSUES AND CELLS |
摘要 |
An composition in a method for noninvasively monitoring the expression of therapeutic transgene delivered ex vivo and in vivo for the treatment of diseases includes the step of quantitatively imaging a reporter gene expression which is coupled to a therapeutic gene on a plasmid vector to infer levels, location, or duration of the therapeutic gene expression in the targeted tissues or organs. The reporter gene is imaged using a radiopharmaceutical for scintigraphic imaging of the gene expression interactions with the reporter gene, namely positron emission tomography, gamma camera or single-photon emission computed tomography. The genes are delivered with a liposome encapsulated reporter-therapeutic linked transgene vector with balanced reporter/therapeutic transgene expression. A transgene composition includes the reporter gene linked to the therapeutic gene or genes incorporated in and delivered by a liposome encapsulated reporter-therapeutic linked transgene vector.
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申请公布号 |
US2009169474(A1) |
申请公布日期 |
2009.07.02 |
申请号 |
US20070280680 |
申请日期 |
2007.03.20 |
申请人 |
THE REGENTSF OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SEN LUYI;GAMBHIR SANJIV S. |
分类号 |
A61K51/06;A61K49/04;C12Q1/68 |
主分类号 |
A61K51/06 |
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