CYTOTOXIC AGENTS COMPRISING NEW TOMAYMYCIN DERIVATIVES AND THEIR THERAPEUTIC USE
摘要
The invention relates to novel tomaymicine derivatives comprising a linker. It also relates to the conjugate molecules that comprise one or more of said tomaymicine derivatives covalently linked to a cell binding agent through a linking group that is present on the linker of the tomaymycin derivative. It also relates to the preparation of the tomaymicine derivatives and of the conjugate molecules.
申请公布号
WO2009016516(A3)
申请公布日期
2009.06.11
申请号
WO2008IB02869
申请日期
2008.07.18
申请人
SANOFI-AVENTIS;BOUCHARD, HERVE;CHARI, RAVI V.J;COMMERCON, ALAIN;DENG, YONGHONG;GAUZY, LAURENCE
发明人
BOUCHARD, HERVE;CHARI, RAVI V.J;COMMERCON, ALAIN;DENG, YONGHONG;GAUZY, LAURENCE