发明名称 |
SUBSTITUTED 2-ARYLBENZAZOLE COMPOUNDS AND THEIR USE AS ANTITUMOUR AGENTS |
摘要 |
Substituted 2-phenylbenzazole compounds of formula (I) wherein X represents S or O and Q represents a direct bond, -CH2- or -CH=CH-, exhibit selective antiproliferative activity in respect of mammalian tumour cells. At least in preferred embodiments the benzene ring of the benzazole nucleus has a halogen substituent, preferably fluorine, and the 2-phenyl group has a 4'-amino substituent which may be conjugated with an amino acid to provide a water soluble amino acid amide prodrug or salt thereof.
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申请公布号 |
CA2382406(C) |
申请公布日期 |
2009.05.19 |
申请号 |
CA20002382406 |
申请日期 |
2000.08.21 |
申请人 |
CANCER RESEARCH VENTURES LIMITED |
发明人 |
CHUA, MEI-SZE;STEVENS, MALCOLM FRANCIS GRAHAM;HUTCHINSON, IAN PAUL;POOLE, TRACEY DAWN;WESTWELL, ANDREW DAVID |
分类号 |
C07D277/66;A61K31/423;A61K31/428;A61K51/04;A61P35/00;C07D263/57;C07D277/64;C07F7/22 |
主分类号 |
C07D277/66 |
代理机构 |
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