The present invention relates to the biotechnological production of the HMG-CoA reductase inhibitor simvastatin by us ing a microorganism capable of producing monacolin J, a transesterase and the addition of 2,2-dimethylbutyric acid or a salt or an ester thereof.
申请公布号
WO2009056539(A1)
申请公布日期
2009.05.07
申请号
WO2008EP64595
申请日期
2008.10.28
申请人
DSM IP ASSETS B.V.;BERG, VAN DEN, MARCO ALEXANDER;HANS, MARCUS;TREFZER, AXEL CHRISTOPH
发明人
BERG, VAN DEN, MARCO ALEXANDER;HANS, MARCUS;TREFZER, AXEL CHRISTOPH
