Gesubstitueerde oxazolidinonen en toepassing daarvan op het terrein van Rivaroxaban, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, hydraat of hydraat van het zout

摘要

N-oxazolidinylmethyl-substituted (benzo)thiophene carboxamides (I) and their salts, hydrates and prodrugs are new. - N-oxazolidinylmethyl-substituted (benzo)thiophene carboxamides of formula (I) and their salts, hydrates and prodrugs are new. - R1 = optionally benzo-fused thiophene, optionally substituted one or more times; - R2 = any selected organic group; - R3-R8 = same or different hydrogen or 1-6C alkyl. - Excluded are compounds where R2 = phenyl (optionally substituted once or more) and all of R3-R8 are hydrogen. - Independent claims are also included for the following: - (1) preparation of (I); and - (2) pharmaceutical composition containing (I), optionally also auxiliaries and carriers. - ACTIVITY - Anticoagulant; cardiant; anti-anginal; vasotropic; thrombolytic; cerebroprotective; antiarthritic; antiarteriosclerotic; cytostatic; nootropic; neuroprotective. - Test details are described but no results given. - MECHANISM OF ACTION - Coagulation factor Xa Inhibitor.