PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 3-QUINUCLIDINOL DERIVATIVE

摘要

Disclosed is a process for producing an optically active 3-quinuclidinol derivative having a high optical purity in high yield by using a readily available ruthenium compound as an asymmetrical reduction catalyst. Specifically disclosed is a process for producing an optically active 3-quinuclidinol derivative represented by the formula (III), which is characterized by asymmetrically hydrogenating a 3-quinuclidinone derivative represented by the formula (I) in the presence of a ruthenium compound (II) represented by the formula (II): Ru(X)(Y)(Px)n[R1R2C*(NR3R4)-A-R5R6C*(NR7R8)] [in the formulae, R represents a hydrogen atom, a C7-C18 aralkyl group or the like; X and Y independently represent a hydrogen atom, a halogen atom or the like; Px represents a phosphine ligand; n represents a numeral number of 1 or 2; R1 to R8 independently represent a hydrogen atom, a C1-C20 alkyl group or the like; * represents an optically active carbon atom; and A represents an ethylene group or the like. [Chemical formula 1] RUTHENIUM COMPOUND (II)(I) (III)