REGULATORY SEQUENCES DERIVED FROM IL-10 PROMOTER AND USES THEREOF IN MODULATION OF IMMUNE RESPONSE

摘要

The present invention relates to a nucleic acid sequence comprising a regulatory element derived from an anti-inflammatory cytokine promoter region. More particularly, the invention relates to novel repressor elements derived from the IL-10 promoter region. The invention further provides transcription factor repressor decoy molecules comprising the regulatory sequences of the invention, as well as immuno-modulatory compositions, methods and uses thereof for modulation of innate immunity and for the treatment of immune related disorders.