The present invention relates to novel human insulin derivatives which are soluble at physiological pH values and have a prolonged profile of action. The invention also relates to methods of providing such derivatives, to pharmaceutical compositions containing them, to methods of treating diabetes and hyperglycaemia using the insulin derivatives of the invention and to the use of such insulin derivatives in the treatment of diabetes and hyperglycaemia.
申请公布号
EP2015770(A2)
申请公布日期
2009.01.21
申请号
EP20070728897
申请日期
2007.05.08
申请人
NOVO NORDISK A/S
发明人
HUBALEK, FRANTISEK;HOEG-JENSEN, THOMAS;JONASSEN, IB;GARIBAY, PATRICK WILLIAM;JAKOBSEN, PALLE;HAVELUND, SVEND;KODRA, JANOS TIBOR