发明名称 |
SUBSTITUTED NUCLEOSIDE DERIVATIVES WITH ANTIVIRAL AND ANTIMICROBIAL PROPERTIES |
摘要 |
The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/ AIDS. |
申请公布号 |
WO2009009625(A2) |
申请公布日期 |
2009.01.15 |
申请号 |
WO2008US69571 |
申请日期 |
2008.07.09 |
申请人 |
EASTERN VIRGINIA MEDICAL SCHOOL;DONCEL, GUSTAVO, F.;PARANG, KEYKAVOUS;AGRAWAL, HITESH, KUMAR |
发明人 |
DONCEL, GUSTAVO, F.;PARANG, KEYKAVOUS;AGRAWAL, HITESH, KUMAR |
分类号 |
A61K31/7072 |
主分类号 |
A61K31/7072 |
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